Skin aging is an inevitable process that is caused by two factors - internal and external, which over time reduce the physiological function of the skin.
Tomorrow's aging occurs due to the constant production of reactive oxygen species (ROS) as a byproduct of mitochondrial aerobic metabolism of the electron transport chain. The result is a decrease in the number of dermal fibroblasts, an increase in the expression of matrix metalloproteinases (MMPs), and a decrease in the ability of the extracellular matrix (ECM) to synthesize collagen and elastin.
Tomorrow's aging occurs due to the constant production of reactive oxygen species (ROS) as a byproduct of mitochondrial aerobic metabolism of the electron transport chain. The result is a decrease in the number of dermal fibroblasts, an increase in the expression of matrix metalloproteinases (MMPs), and a decrease in the ability of the extracellular matrix (ECM) to synthesize collagen and elastin.
Extrinsic aging is a consequence of long-term exposure to ultraviolet radiation, which stimulates the production of ROS, which causes destructive oxidative stress, activates the arachidonic acid pathway, and mediates inflammatory responses.
As a result of these processes, the skin becomes dry, less elastic, laxity, fine lines and wrinkles appear.
Humanity tries in various ways to fight and slow down the aging process.
Recently, one of the popular anti-aging products are preparations based on PN/PDRN - nucleic acids, which are endowed with a very powerful regenerating effect. The use of polynucleotides makes it possible not only to stop the aging process, but also to restore youth to our skin.
In medicine, PN/PDRN has been used to treat some complex diseases for over a hundred years. They are in cosmetology began to be used relatively recently. During this time, polynucleotides managed to receive a lot of positive reviews and are now actively used by cosmetologists for skin rejuvenation all over the world.
Their main advantage is that they have a restorative and immunomodulating effect at the cellular level. That is why the method of rejuvenation with polynucleotides is called bioreparation.
In medicine, PN/PDRN has been used to treat some complex diseases for over a hundred years. They are in cosmetology began to be used relatively recently. During this time, polynucleotides managed to receive a lot of positive reviews and are now actively used by cosmetologists for skin rejuvenation all over the world.
Their main advantage is that they have a restorative and immunomodulating effect at the cellular level. That is why the method of rejuvenation with polynucleotides is called bioreparation.
What is PN/PDRN in modern cosmetology?
PN/PDRN, also called polynucleotides or polydeoxyribonucleotides, is a natural building block in DNA that helps repair damaged skin cells, stimulates collagen production, and has anti-ischemic and anti-inflammatory properties.
They consist of fragments of DNA obtained from the sperm of Oncorhynchus mykiss (salmon trout) or Oncorhynchus keta (keta), which is very similar to human DNA.
Action of PN/PDRN in tissues and result:
-
increases the metabolic activity of fibroblasts, which stimulate the production of collagen proteins, which leads to an increase in turgor and skin tone;
-
activates receptors that are responsible for the formation of new blood vessels, and also create environment for the restoration of damaged tissues, which in turn, promotes natural regeneration;
-
synthesizes fibrillar fibers, elastin, glycosaminoglycans, which ensures the growth of tissue elasticity and firmness;
-
activates the process of angiogenesis, which helps in the treatment of couperosis and optimization of microcirculation;
-
helps produce hyaluronic acid - provides skin hydration;
-
normalizes melanin production;
- has antioxidant properties.
Why is PN/PDRN taken from sperm DNA?
You have probably wondered more than once why spermatozoa are used to obtain PDRN, and not any other cell of the body.
The answer is very simple: somatic cells of the body, with the exception of eggs and spermatozoa, during processing have the risk of transferring impurities (residues), such as proteins, peptides and lipids, to the drug. At that time, sperm cells, which are extracted and purified at high temperature, do not have such risks.
The answer is very simple: somatic cells of the body, with the exception of eggs and spermatozoa, during processing have the risk of transferring impurities (residues), such as proteins, peptides and lipids, to the drug. At that time, sperm cells, which are extracted and purified at high temperature, do not have such risks.
Advantages and applications
PN/PDRN has several excellent properties that help effectively fight skin aging:
-
regenerates tissues, reduces visible signs of aging, helps fight deep wrinkles and fine lines, as well as skin laxity;
-
moisturizes, improves elasticity, tone and texture of the skin, strengthens the natural barrier of the skin, to prevent further damage;
-
helps restore damaged skin cells;
-
stimulates the production of collagen and elastin;
-
protects against free radicals (active forms of oxygen);
-
reduces hyperpigmentation by suppressing melanogenesis, gives the skin radiance;
-
has an anti-inflammatory effect.
Indications for use:
-
wrinkles, thin lines, "crow's feet";
-
dark circles under the eyes;
-
dull skin or uneven tone;
-
loss of firmness, elasticity and tone of the skin;
-
loose skin;
-
enlarged pores;
-
atonic skin;
-
pigmentation;
-
acne scars;
-
dry skin;
-
peeling of the skin and actinic keratosis.
-
comprehensive treatment of scars and stretch marks.
What is the difference between PDRN and PN?
Polynucleotides (PN), unlike PRDN, are more purified and concentrated and belong to a wider group of molecules. PRDN (polydeoxyribonucleotides) belong to the PN subtype.
The difference between the use of fillers and polynucleotides (PDRN)
Fillers can help reduce the appearance of wrinkles, fine lines, and hollows by augmenting soft tissue, but they play almost no role in the actual anti-aging process.
Unlike dermal fillers, PN/PDRN enhance regeneration in the environment of damaged tissue. Preparations with polynucleotides:
- promote biostimulation and influence fibroblasts, which leads to tissue regeneration;
- stimulate the production of own hyaluronic acid;
- capable of binding water molecules;
- are optimally distributed in the intercellular space of the dermis.
All this provides hydration, elasticity, density, turgor, tone of the skin and effectively helps fight against its aging.
How many procedures are necessary to achieve the result?
The result after using PN/PDRN is not as fast and expressive as, for example, after injections of hyaluronic acid. This is due to the mechanism of action of polynucleotides, the main tasks of which are tissue regeneration, cell repair and fibroblast stimulation, and this process requires a certain amount of time.
To get the desired and visible results, you need to go through several sessions. It is recommended to carry out at least 2-3 procedures with an interval of once every 2 weeks, followed by maintenance treatment once or twice a year.
To get the desired and visible results, you need to go through several sessions. It is recommended to carry out at least 2-3 procedures with an interval of once every 2 weeks, followed by maintenance treatment once or twice a year.
Are there any complications or side effects from using PDRN?
PN/PDRN preparations, as mentioned above, are made from salmon or catfish sperm. Their DNA and human DNA are very similar. These circumstances and production technology allow the use of polynucleotides without any risk or harm to humans, including genetic changes in the body, causing allergic reactions.
PN/PDRN is well tolerated by clients. The only discomfort can be bruising and itching at the injection site, which is inherent in any mesotherapy.
PN/PDRN is well tolerated by clients. The only discomfort can be bruising and itching at the injection site, which is inherent in any mesotherapy.
Contraindication
PDRN is not recommended, as for most cases of mesotherapy:
- persons under the age of 18;
- individual intolerance of the drug;
- during pregnancy or lactation.
- presence of autoimmune diseases;
- with diabetes;
- infections and colds in the acute stage;
- epilepsy;
- in case of open ulcers, wounds or damaged skin in the area where the injection is planned.
